The Influence of Probiotic Supplementation on Depression, Anxiety, and Stress Level, as well as Inflammation, Anthropometric and Metabolic Parameters in Patients with Depressive Disorders - preliminary results of an RCT

Introduction There is a huge need to search for new treatment options depression but as well its comorbidities. Particularly, and metabolic abnormalities often coexist, while pathophysiological overlap, including microbiota changes, may play role. Thus, the trials of interventions (e.g., probiotics) establish safe easy-to-use option an adjunctive therapy in patients only partially responsive pharmacological treatment. Objectives The paper presents preliminary results RCT on effect probiotic supplementation depression, anxiety stress level, anthropometric, metabolic, inflammatory parameters adult with depressive disorders. Methods trial was two-arm, parallel-group, prospective, randomized, double-blind, controlled design that included 43 participants lasted 60 days. preparation contained Lactobacillus helveticus Rosell®-52 Bifidobacterium longum Rosell®-175 amount 3 × 10 9 colony forming units (CFU). We assessed level Montgomery-Asberg Depression Rating Scale (MADRS), depressiveness, 21-item version Depression, Anxiety Stress (DASS-21), quality life, blood pressure, body mass index waist circumference, complete count, serum levels C-reactive protein, high-density lipoprotein cholesterol, triglycerides, fasting glucose, selected secondary markers inflammation risk, noninvasive biomarkers liver fibrosis (APRI FIB-4). Results were no differences sociodemographic traits psychometric questionnaires scores, anthropometric basic laboratory findings between placebo group at start intervention period. Interestingly, there statistically significant improvement MADRS score both, (p=0,010) (p=0,037) after (see figure). same finding observed total DASS-21 subscale DASS-21. However, or end study regardless intervention. Image: Conclusions Whilst probiotics benefit some individuals who do not fully respond antidepressant medications, our did show superiority over managing symptoms. target clinical sample, period dosage this recognized. Moreover, larger sample be needed detect probiotics. Disclosure Interest None Declared